Abstract

Evaluation of the prognosis of patients with breast cancer is criticai in determining post-surgical adjuvant therapy because of great heterogeneity in response to the therapy, At present, the decision-making for adjuvant therapy largely depends on histologic nodal status, but a significant number of patients without nodal involvement undergo relapse. Although great efforts have been made for more accurate and potent factors, significant indicators have not yet been found. One of the promising candidates, however, is histologic angiogenesis in tumors, which we and others have indicated as an independent prognostic factor in node-negative subset by the multivariate analysis. Here we will evaluate several prognostic factors in clinical use.

Abstract

Pituitary adenomas are slow growing, benign lesions originating from various hormone producing cells of the anterior lobe of the pituitary gland. The currently used morphofunctional classification is based on histology, immunocytochemistry and electron microscopy. Pituitary adenomas may present clinically with certain endocrinopathies attributable to pituitary hypersecretion of pituitary hormones, or with neurologic symptoms of tumor mass effect due to compression of the adjacent brain structures, such as optic or other cranial nerves, and may induce increased intracranial pressure.